反应条件
1: hydrogenchloride / tetrahydrofuran / 20 °C / Cooling with ice
2: palladium 10 on activated carbon; hydrogen / ethanol / 24 h / 20 °C
3: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C / Molecular sieve
View Scheme
参考文献
Arikawa, Yasuyoshi; Nishida, Haruyuki; Kurasawa, Osamu; Hasuoka, Atsushi; Hirase, Keizo; Inatomi, Nobuhiro; Hori, Yasunobu; Matsukawa, Jun; Imanishi, Akio; Kondo, Mitsuyo; Tarui, Naoki; Hamada, Teruki; Takagi, Terufumi; Takeuchi, Toshiyuki; Kajino, Masahiro
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4446 - 4456
