1: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride in ethylene glycol diethyl ether; water
T=100°C; 1 h;
2: With sodium hydroxide in ethylene glycol diethyl ether; water
T=90°C; 3 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/36024 A1, 2006 ;
Location in patent: Page/Page column 199; 293 ;
