2-(1H-(1,2,3)三氮唑-4-基)-吡啶合成路线 （共 5 条）
反应条件
methanol; copper(l) iodide; trimethylsilylazide in N,N-dimethyl-formamide
T=100°C; Inert atmosphere;
参考文献
Wang, Dong; Denux, Dominique; Ruiz, Jaime; Astruc, Didier
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 129 - 142
反应条件
sodium hydroxide in methanol
T=85°C; 24 h;
参考文献
Loren, Jon C.; Krasinski, Antoni; Fokin, Valery V.; Sharpless, K. Barry
Synlett, 2005 , # 18 art. no. Y06505ST, p. 2847 - 2850
反应条件
sodium hydroxide in methanol
T=20°C; 0.5 h;
参考文献
Loren, Jon C.; Krasinski, Antoni; Fokin, Valery V.; Sharpless, K. Barry
Synlett, 2005 , # 18 art. no. Y06505ST, p. 2847 - 2850
反应条件
hydrogenchloride; potassium fluoride in ethanol
1.5 h; Heating;
参考文献
Aoyama, Toyohiko; Sudo, Kimio; Shioiri, Takayuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3849 - 3851
反应条件
1: 92 percent / n-butyl lithium / hexane; diethyl ether / 2.8 h / 0 °C
2: 86 percent / potassium fluoride, cc. HCl / ethanol / 1.5 h / Heating
View Scheme
参考文献
Aoyama, Toyohiko; Sudo, Kimio; Shioiri, Takayuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3849 - 3851
