water; sodium hydroxide in ethanol T=20°C; 12 h;

1.1: triethylamine / tetrahydrofuran / 2 h / 60 - 70 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere 3.2: 0 - 80 °C / Inert atmosphere 4.1: sodium methylate / methanol / -8 - 5 °C 5.1: anhydrous xylene / 6.33 h / Reflux 6.1: water; sodium hydroxide / ethanol / 12 h / 20 °C View Scheme

1: anhydrous xylene / 6.33 h / Reflux 2: water; sodium hydroxide / ethanol / 12 h / 20 °C View Scheme

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere 2.2: 0 - 80 °C / Inert atmosphere 3.1: sodium methylate / methanol / -8 - 5 °C 4.1: anhydrous xylene / 6.33 h / Reflux 5.1: water; sodium hydroxide / ethanol / 12 h / 20 °C View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere 1.2: 0 - 80 °C / Inert atmosphere 2.1: sodium methylate / methanol / -8 - 5 °C 3.1: anhydrous xylene / 6.33 h / Reflux 4.1: water; sodium hydroxide / ethanol / 12 h / 20 °C View Scheme

1: sodium methylate / methanol / -8 - 5 °C 2: anhydrous xylene / 6.33 h / Reflux 3: water; sodium hydroxide / ethanol / 12 h / 20 °C View Scheme