2-氯-N4-[(4-甲氧基苯基)甲基]-3,4-吡啶二胺合成路线 （共 7 条）
反应条件
1: 20.1 g / acetic anhydride / 1.5 h / Heating 2: 15.6 g / trifluoroacetic acid / 2 h / 80 °C View Scheme
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
iron; acetic acid
T=40°C; 10 h;
参考文献
Myrexis, Inc.
Patent: US8017780 B1, 2011 ;
Location in patent: Page/Page column 85 ;
反应条件
hydrogenchloride in methanol; water
参考文献
Cai, Xiong; Qian, Changgeng
Patent: US2010/184801 A1, 2010 ;
反应条件
1: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C
2: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C
View Scheme
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
1: 77 percent / POCl3 / 90 - 100 °C
2: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C
3: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C
View Scheme
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
1: triethylamine / N,N-dimethyl-formamide / 10 h / 0 - 20 °C
2: acetic acid; iron / 10 h / 40 °C
View Scheme
参考文献
Myrexis, Inc.
Patent: US8017780 B1, 2011 ;
反应条件
acetic anhydride
1.5 h; Heating;
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
