trifluoroacetic acid T=80°C; 2 h;

1: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C 2: 20.1 g / acetic anhydride / 1.5 h / Heating View Scheme

1: 77 percent / POCl3 / 90 - 100 °C 2: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C 3: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C 4: 20.1 g / acetic anhydride / 1.5 h / Heating View Scheme

1: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C 2: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C 3: 20.1 g / acetic anhydride / 1.5 h / Heating View Scheme

acetic anhydride 1.5 h; Heating;