(R)-(+)-1-(3-甲氧基苯基)乙胺合成路线 （共 22 条）
反应条件
glucose dehydrogenase; D-glucopyranose; [3H]-L-Alanine; Vibrio fluvialis ω-transaminase; β-nicotinamide adenine dinucleotide; lactate dehydrogenase in dimethyl sulfoxide T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Fuchs, Michael; Koszelewski, Dominik; Tauber, Katharina; Kroutil, Wolfgang; Faber, Kurt
Chemical Communications, 2010 , vol. 46, # 30 p. 5500 - 5502
反应条件
1: With C5H12BNO in tetrahydrofuran T=20°C; 24 h; 2: With borane-THF in tetrahydrofuran 24 h; Reflux; optical yield given as percent eeenantioselective reactionFurther stages;
参考文献
Pakulski, Marcin M.; Mahato, Sanjit K.; Bosiak, Mariusz J.; Krzeminski, Marek P.; Zaidlewicz, Marek
Tetrahedron Asymmetry, 2012 , vol. 23, # 9 p. 716 - 721
反应条件
1: With C10H18BNO in tetrahydrofuran T=20°C; 24 h; 2: With borane-THF in tetrahydrofuran 24 h; Reflux; optical yield given as percent eeenantioselective reactionFurther stages;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 9 p. 716 - 721
反应条件
hydrogenchloride in methanol; diethyl ether T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Organic Syntheses, 2013 , vol. 90, p. 338 - 349
反应条件
hexacarbonyl molybdenum in water; acetonitrile T=85°C; 1 h;
参考文献
Atobe, Masakazu; Yamazaki, Naoki; Kibayashi, Chihiro
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5595 - 5607
反应条件
1: With ammonium acetate; sodium cyanoborohydride in methanol T=20°C; reductive amination; 2: racemate resolution; Further stages.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 7 p. 1339 - 1347
反应条件
sodium hydroxide in water; ethyl acetate pH=~ 9 - ~ 10; 0.5 h;
参考文献
WO2011/70585 A1, ;
Page/Page column 13-14 ;
反应条件
1: With periodic acid; methylamine in methanol; water T=20°C; 3 h; 2: With hydrogenchloride in methanol 0.5 h; Further stages.;
参考文献
Lamblin, Marc; Couture, Axel; Deniau, Eric; Grandclaudon, Pierre
Tetrahedron Asymmetry, 2008 , vol. 19, # 1 p. 111 - 123
反应条件
solid phase supported Candida antarctica lipase type B in tert-butyl methyl ether T=45°C; 19 h; Inert atmosphereEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 74, # 15 p. 5304 - 5310
反应条件
1.1: (R,R)-BozPHOS; Cu(OTf)2 / toluene / 0.5 h / 20 °C 1.2: 67 percent / toluene / 48 h / 20 °C 2.1: aq. HCl / methanol / 4 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 47 p. 14260 - 14261
