1: 75 percent / pyridine / 12 h / Ambient temperature 2: 77 percent / NaH / dimethylformamide / 0.75 h / 0 °C 3: 39 percent / H2O / 0.17 h / Heating View Scheme

1: 75 percent / pyridine / 12 h / Ambient temperature 2: 53 percent / PCl5 / CH2Cl2 / 0.08 h 3: 54 percent / Et3N / CH2Cl2 / 12 h 4: 50 percent / potassium t-butoxide / tetrahydrofuran / 1 h / 0 °C View Scheme

1: 75 percent / pyridine / 12 h / Ambient temperature 2: 53 percent / PCl5 / CH2Cl2 / 0.08 h 3: 59 percent / Et3N / CH2Cl2 / 12 h 4: 22 percent / potassium t-butoxide / tetrahydrofuran / 1 h / 0 °C View Scheme

1: 75 percent / pyridine / 12 h / Ambient temperature 2: 53 percent / PCl5 / CH2Cl2 / 0.08 h 3: 59 percent / Et3N / CH2Cl2 / 12 h 4: 22 percent / potassium t-butoxide / tetrahydrofuran / 1 h / 0 °C 5: 40 percent / tetrahydrofuran / 1 h View Scheme

1: 75 percent / pyridine / 12 h / Ambient temperature 2: 63 percent / 1M hydrochloric acid / H2O / 3 h / Heating View Scheme

1: 75 percent / pyridine / 12 h / Ambient temperature 2: 77 percent / NaH / dimethylformamide / 0.75 h / 0 °C View Scheme