1: 98 percent / H2 / PtO2 / ethanol / 3 h / 23 °C 2: 96 percent / tetrahydrofuran / 1.5 h / -78 °C 3: 39 percent / Et3SiH; BF3*OEt2 / CH2Cl2; 2,2,2-trifluoro-ethanol / 3 h / -78 °C 4: TFA / CH2Cl2 / 0 - 23 °C 5: 86 percent / N,N-diisopropylethylamine; HATU / acetonitrile / 12 h / 23 °C 6: 67 percent / Grela's catalyst / CH2Cl2 / 9 h / 23 °C 7: 90 percent / tetrahydrofuran / 0 - 23 °C 8: 28 percent / Grela's catalyst / 1,2-dichloro-ethane / 10 h / 23 °C View Scheme