5-氟-1H-吡咯并[2,3-B]吡啶 7-氧化物合成路线 (共 3 条)
反应条件
1: With methyl chloroformate; 1,1,1,3,3,3-hexamethyl-disilazane in tetrahydrofuran T=5°C; 3 h; 2: With sodium hydroxide in tetrahydrofuran T=10°C; 2 h; 3: With hydrogenchloride in tetrahydrofuran; water pH=7;
参考文献
ELI LILLY AND COMPANY; LAMAS-PETEIRA, Carlos; RICHARDS, Simon, James; SAPMAZ, Selma; WALTER, Magnus, Wilhelm
Patent: WO2012/74769 A1, 2012 ;
Location in patent: Page/Page column 32 ;
WO 2012/074769 A1
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in ethylene glycol dimethyl ether
T=20°C; 1.5 h;
2: With potassium hydroxide in methanol; ethylene glycol dimethyl ether
参考文献
Aventis Pharma S.A.
Patent: US2007/93480 A1, 2007 ;
Location in patent: Page/Page column 64 ;
反应条件
1: With trichlorophosphate
8 h; Heating / reflux;
2: With sodium hydrogencarbonate in water
T=0°C; pH=8 - 9;
参考文献
Aventis Pharma S.A.
Patent: US2007/93480 A1, 2007 ;
Location in patent: Page/Page column 64 ;