3-氟-4-亚甲基哌啶-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran
T=-78°C; 2 h;
2: 1-Boc-3-fluoropiperidin-4-one in tetrahydrofuran
T=-78 - 20°C; Wittig reaction;
参考文献
Koudih, Radouane; Gilbert, Gwenaelle; Dhilly, Martine; Abbas, Ahmed; Barre, Louisa; Debruyne, Daniele; Sobrio, Franck
European Journal of Medicinal Chemistry, 2012 , vol. 53, p. 408 - 415
反应条件
potassium hydride in tetrahydrofuran
T=0°C; Peterson elimination; 1 h;
参考文献
Di Fabio, Romano; Giovannini, Riccardo; Bertani, Barbara; Borriello, Manuela; Bozzoli, Andrea; Donati, Daniele; Falchi, Alessandro; Ghirlanda, Damiano; Leslie, Colin P.; Pecunioso, Angelo; Rumboldt, Giovanna; Spada, Simone
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1749 - 1752
反应条件
1: 57 percent / tetrahydrofuran / 1.5 h / 0 °C
2: 89 percent / KH / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Di Fabio, Romano; Giovannini, Riccardo; Bertani, Barbara; Borriello, Manuela; Bozzoli, Andrea; Donati, Daniele; Falchi, Alessandro; Ghirlanda, Damiano; Leslie, Colin P.; Pecunioso, Angelo; Rumboldt, Giovanna; Spada, Simone
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1749 - 1752
