in N,N-dimethyl-formamide T=110°C; 20 h;

1: 85 percent / NaOEt / ethanol / 2 h / Heating 2: 60 percent / dimethylformamide / 20 h / 110 °C View Scheme

1: 93 percent / NaOH / H2O; diethyl ether / 1.) 10 deg C, 1h, 2.) r.t., 3 h 2: 85 percent / NaOEt / ethanol / 2 h / Heating 3: 60 percent / dimethylformamide / 20 h / 110 °C View Scheme

sodium 1.) dimethylformamide, 24 h., 2.) dimethylformamide, add over 75 min. and heating another 5 h.; Yield given. Multistep reaction;