5,6-二甲氧基吲哚-2-甲酸合成路线 （共 12 条）
反应条件
lithium hydroxide; water in 1,4-dioxane T=25°C; 12 h;
参考文献
The Scripps Research Institute
Patent: US2005/26987 A1, 2005 ;
Location in patent: Page 20 ;
反应条件
1: With sodium hydroxide in methanol; water 1 h; Heating; 2: With hydrogenchloride in methanol; water T=20°C; 14 h;
参考文献
Choi, Taeyoung; Ma, Eunsook
Archives of Pharmacal Research, 2011 , vol. 34, # 3 p. 357 - 367
反应条件
air; tyrosine ase from meal worms; water T=26 - 30°C; pH 6-6,5, Reduktion der erhaltenen Loesung mit Schwefeldioxyd und Methylierung des Reaktionsprodukts mit Dimethylsulfat und Natronlauge;
参考文献
Journal of the Chemical Society, , p. 2061,2064
Biochemical Journal, , vol. 21, p. 95
Physiol. Rev., , vol. 30, p. 96
Journal of Biological Chemistry, , vol. 172, p. 83,90, 94
反应条件
1: xylene / 0.25 h / Heating 2: KOH / H2O / 1 h / Heating View Scheme
参考文献
Molecules, , vol. 11, # 12 p. 968 - 977
反应条件
1: sodium methoxide / methanol / 4 h / -15 °C 2: xylene / 0.25 h / Heating 3: KOH / H2O / 1 h / Heating View Scheme
参考文献
Molecules, , vol. 11, # 12 p. 968 - 977
反应条件
1: copper(l) iodide; caesium carbonate / dimethyl sulfoxide / 80 °C 2: water; sodium hydroxide / ethanol / 20 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 7 p. 550 - 554
反应条件
1: xylene / 140 - 145 °C 2: 90 percent / 2N aq. NaOH / 6 h / 100 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 30 p. 5413 - 5416
反应条件
1.1: anhydrous xylene / Reflux 2.1: sodium hydroxide / methanol; water / 1 h / Heating 2.2: 14 h / 20 °C View Scheme
参考文献
Archives of Pharmacal Research, , vol. 34, # 3 p. 357 - 367
反应条件
1: 61 percent / Cu; quinoline / Heating 2: 86 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
copper in quinoline 2 h; Heating;
参考文献
Sreenivasa Reddy; Cook, James M.
Tetrahedron Letters, 1994 , vol. 35, # 30 p. 5413 - 5416
