5,6-二甲氧基吲哚-2-甲酸合成路线 (共 12 条)
反应条件
boron tribromide in dichloromethane T=-78 - 20°C;
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 7 p. 550 - 554
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; 1,4-dioxane
T=0°C; 31 h; Reflux;
参考文献
IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin
Patent: WO2012/88469 A1, 2012 ;
Location in patent: Page/Page column 129-130 ;
WO 2012/088469 A1