1: 2-(2-(benzyloxy)ethyl)-2-methylpropane-1,3-diol With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: p-toluenesulfonyl chloride in tetrahydrofuran; hexane T=0°C; 1 h; 3: With n-butyllithium in tetrahydrofuran; hexane T=60°C; 6 h;

sodium methylate in methanol 1.) 20 deg C, 16 h, 2.) reflux, 4 h;

1: 1.) NaH, 2.) NaI / 1.) DMF, THF, light petroleum, reflux, 30 min, 2.) reflux, 24 h 2: 92 percent / LiAlH4 / diethyl ether / 4 h / Heating 3: tetrahydrofuran; CCl4 / -40 deg C -> 20 deg C 4: 8.84 g / NaOMe / methanol / 1.) 20 deg C, 16 h, 2.) reflux, 4 h View Scheme

1: tetrahydrofuran; CCl4 / -40 deg C -> 20 deg C 2: 8.84 g / NaOMe / methanol / 1.) 20 deg C, 16 h, 2.) reflux, 4 h View Scheme

1: 92 percent / LiAlH4 / diethyl ether / 4 h / Heating 2: tetrahydrofuran; CCl4 / -40 deg C -> 20 deg C 3: 8.84 g / NaOMe / methanol / 1.) 20 deg C, 16 h, 2.) reflux, 4 h View Scheme