in toluene T=120°C; 12 h; Inert atmosphere;

1: 3-indol-3-yl-acrylic acid ethyl ester With sodium hydride in tetrahydrofuran; mineral oil T=0°C; 0.25 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; mineral oil T=20°C; 1 h; Inert atmosphere;

1.1: dichloromethane / 6 h / 20 °C / |Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / |Inert atmosphere 2.2: 1 h / 20 °C / |Inert atmosphere View Scheme