2-氨基-5-溴异烟酸甲酯合成路线 （共 4 条）
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=-18°C; 1 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/113226 A1, 2007 ;
Location in patent: Page/Page column 126-127 ;
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=70°C; 2 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; methanol; water T=0°C; pH=6;
参考文献
PRESIDIO PHARMACEUTICALS, INC.; ZHONG, Min; LI, Leping
Patent: WO2012/58125 A1, 2012 ;
Location in patent: Page/Page column 145 ;
WO 2012/058125 A1
反应条件
sodium hydrogencarbonate in ethanol 14 h; Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/113226 A1, 2007 ;
Location in patent: Page/Page column 126-127 ;
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol
T=70°C; 2 h; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
T=0°C; pH=6;
参考文献
PRESIDIO PHARMACEUTICALS, INC.; ZHONG, Min; LI, Leping
Patent: WO2012/58125 A1, 2012 ;
Location in patent: Page/Page column 145 ;
WO 2012/058125 A1
