1,1'-carbonyldiimidazole in N,N-dimethyl-formamide

in N,N-dimethyl-formamide T=55°C; 2.5 h;

1: 85 percent / 20percent NaOH / 24 h / 140 °C / pressure vessel 2: 100 percent / dimethylformamide / 2.5 h / 55 °C View Scheme

1: 96 percent / 2-methyl-propan-2-ol / 3.5 h / 70 °C 2: 1) lithium diisopropylamide / 1) THF, -30 deg C, 2.5 h, 2) THF, -30 deg C, 2 h, then to O deg C during 1 h 3: 93 percent / H2SO4, acetic anhydride 4: 5.5 g / 20percent NaOH / 40 h / Heating View Scheme