4-溴-N,N,3-三甲基-1H-吡唑-1-磺酰胺合成路线 （共 2 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane in acetonitrile
T=20°C; 6 h;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2006/136830 A1, 2006 ;
Location in patent: Page/Page column 186 ;
WO 2006/136830 A1
反应条件
1: With methyllithium in tetrahydrofuran; diethyl ether
T=-55 - 20°C;
2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2006/136830 A1, 2006 ;
Location in patent: Page/Page column 186-187 ;
WO 2006/136830 A1
