3-溴-2-甲氧基苯甲醛合成路线 （共 19 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
JANSSEN PHARMACEUTICALS, INC.; MINNE, Garrett, Berlond; BISCHOFF, François Paul; GIJSEN, Henricus, Jacobus, Maria; VELTER, Adriana, Ingrid; PIETERS, Serge, Maria, Aloysius; BERTHELOT, Didier, Jean-Claude
Patent: WO2013/10904 A1, 2013 ;
Location in patent: Page/Page column 65 ;
反应条件
1: 3-bromo-2-hydroxybenzaldehyde With caesium carbonate in DMF (N,N-dimethyl-formamide) 0.5 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) 20 h;
参考文献
WO2004/50637 A2, ;
Page 74-75 ;
WO 2004/050637 A2
反应条件
dimethylsulfide; ozone in methanol; dichloromethane 12 h;
参考文献
Comber, Mark F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , p. 2783 - 2787
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; trimethylsilyl trifluoromethanesulfonate in dichloromethane 2 h;
参考文献
Chassaing, Christophe; Haudrechy, Arnaud; Langlois, Yves
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4415 - 4416
反应条件
ozone in methanol; hexane; ethyl acetate; tert-butyl alcohol
反应条件
1.1: potassium carbonate / acetone / 1 h / Heating 2.1: 10.8 g / 50 h / 240 °C 3.1: O3 / CH2Cl2 / -78 °C 3.2: 72 percent / triphenylphosphine / 24 h / 20 °C 4.1: 94 percent / potassium carbonate / dimethylformamide / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3573 - 3575
反应条件
1.1: 10.8 g / 50 h / 240 °C 2.1: O3 / CH2Cl2 / -78 °C 2.2: 72 percent / triphenylphosphine / 24 h / 20 °C 3.1: 94 percent / potassium carbonate / dimethylformamide / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3573 - 3575
反应条件
1: 88 percent / KOt-Bu / 2-methyl-propan-2-ol 2: basic alumina (Woelm, akt I) / hexane; ethyl acetate / by eluting through a column 3: O3 View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 36 p. 3955 - 3958
反应条件
1: basic alumina (Woelm, akt I) / hexane; ethyl acetate / by eluting through a column 2: O3 View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 36 p. 3955 - 3958
反应条件
1: 91 percent / benzene / 20 h / Heating 2: 95 percent / 90percent aq. TFA / 0.25 h 3: 84 percent / KOAc / 0.08 h / Heating View Scheme
参考文献
Comber; Sargent
Journal of the Chemical Society - Series Chemical Communications, 1991 , # 3 p. 190 - 192
