4,4-二甲基-1-氧代-1,2,3,4-四氢-2-萘甲酸合成路线 (共 5 条)
反应条件
sodium hydroxide in ethanol
4 h; Ambient temperature;
参考文献
Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 306 - 310
反应条件
1: 81 percent / NaH / tetrahydrofuran / 16 h / Heating
2: 81 percent / 2,3-dichloro-5,6-dicyanobenzoquinone, AcOH / tetrahydrofuran / 16 h / Ambient temperature
3: 40 percent / aq. NaOH / 2 h / Heating
View Scheme
参考文献
Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 306 - 310
反应条件
1: 81 percent / 2,3-dichloro-5,6-dicyanobenzoquinone, AcOH / tetrahydrofuran / 16 h / Ambient temperature
2: 40 percent / aq. NaOH / 2 h / Heating
View Scheme
参考文献
Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 306 - 310
反应条件
1: 67 percent / AlCl3
2: 81 percent / NaH / tetrahydrofuran / 16 h / Heating
3: 81 percent / 2,3-dichloro-5,6-dicyanobenzoquinone, AcOH / tetrahydrofuran / 16 h / Ambient temperature
4: 40 percent / aq. NaOH / 2 h / Heating
View Scheme
参考文献
Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 306 - 310
反应条件
sodium hydroxide
2 h; Heating;
参考文献
Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 306 - 310