N-(3-羟丙基)酞亚胺合成路线 （共 19 条）
反应条件
Oxonereg;; 2-iodo benzoic acid in water; acetonitrile T=70°C; 6 h;
参考文献
Thottumkara, Arun P.; Bowsher, Michael S.; Vinod, Thottumkara K.
Organic Letters, 2005 , vol. 7, # 14 p. 2933 - 2936
反应条件
in benzene T=50 - 85°C;
参考文献
Wood, Michael R.; Kim, June Y.; Books, Kathy M.
Tetrahedron Letters, 2002 , vol. 43, # 21 p. 3887 - 3890
反应条件
2-iodoxybenzoic acid in ethyl acetate 2 h; Reflux;
参考文献
EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.
Patent: WO2012/82436 A2, 2012 ;
Location in patent: Page/Page column 245-246 ;
WO 2012/082436 A2
反应条件
sodium bromide; anhydrous sodium hydrogen carbonate; 3'-phenoxy-4'-fluoro-α'-cyanobenzyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropane-carboxylate in dichloromethane
参考文献
JEPPESEN, LONE; ANDERSEN, HENRIK SUNE; OLSEN, OLE HVILSTED; JUDGE, LUKE MILBURN; HOLSWORTH, DANIEL DALE; BAKIR, FARID; AXE, FRANK URBAN; GE, YU
Patent: US2002/2199 A1, 2002 ;
反应条件
triethylamine in dichloromethane T=-78°C; 1 h;
参考文献
Prabhakaran,P.C.; Gould,S.J.; Orr,G.R.
Journal of the American Chemical Society, 1988 , vol. 110, p. 5779
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=20°C; Mitsunobu reaction; Inert atmosphere;
参考文献
Pascale, Rossana; Carocci, Alessia; Catalano, Alessia; Lentini, Giovanni; Spagnoletta, Anna; Cavalluzzi, Maria Maddalena; De Santis, Francesco; De Palma, Annalisa; Scalera, Vito; Franchini, Carlo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 16 p. 5903 - 5914
反应条件
1: With diisopropyl-carbodiimide; copper(l) chloride in tetrahydrofuran
T=100°C; 0.0833333 h; microwave irradiation;
2: With acetyl chloride in tetrahydrofuran
T=150°C; 0.0833333 h; microwave irradiation; Further stages.;
参考文献
Crosignani, Stefano; Nadal, Brice; Li, Zhengning; Linclau, Bruno
Chemical Communications, 2003 , # 2 p. 260 - 261
反应条件
1: 86 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
2: 95 percent / NaOH; Et3N / CH2Cl2; H2O / 1 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Zhang, Junyi; Xiong, Chiyi; Ying, Jinfa; Wang, Wei; Hruby, Victor J.
Organic Letters, 2003 , vol. 5, # 17 p. 3115 - 3118
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
4 h; Inert atmosphereSchlenk technique;
参考文献
Levin, Vitalij V.; Zemtsov, Artem A.; Struchkova, Marina I.; Dilman, Alexander D.
Organic Letters, 2013 , vol. 15, # 4 p. 917 - 919
