7-溴-5-氟-3-甲基-1H-吲哚合成路线 （共 5 条）
反应条件
triethylamine; palladium diacetate; tris-(o-tolyl)phosphine in acetonitrile 2 - 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
DECODE GENETICS EHF
Patent: WO2007/137040 A2, 2007 ;
Location in patent: Page/Page column 18 ;
反应条件
in tetrahydrofuran T=-50°C; 1 h;
参考文献
Zegar, Siead; Tokar, Christopher; Enache, Livia A.; Rajagopol, Venkat; Zeller, Wayne; O'Connell, Matthew; Singh, Jasbir; Muellner, Frank W.; Zembower, David E.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 747 - 753
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 20 °C / |Inert atmosphere; |Large scale 1.2: 1.58 h / 10 - 20 °C / |Inert atmosphere; |Large scale 2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / acetonitrile / 5 h / |Reflux; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 4 p. 747 - 753
反应条件
triethylamine; palladium diacetate; tris-(o-tolyl)phosphine in acetonitrile
T=20°C; Heck Reaction; 3.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
DECODE GENETICS, EHF.
Patent: US2007/270594 A1, 2007 ;
Location in patent: Page/Page column 9 ;
反应条件
1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / acetonitrile / |Inert atmosphere; |Reflux; |Large scale
2: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
Zegar, Siead; Tokar, Christopher; Enache, Livia A.; Rajagopol, Venkat; Zeller, Wayne; O'Connell, Matthew; Singh, Jasbir; Muellner, Frank W.; Zembower, David E.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 747 - 753
