hydrogenchloride in 1,2-dichloro-ethane T=50°C; 10 h; Heating;

1: Et3N / CH2Cl2 / 0 °C 2: TMEDA, n-BuLi / diethyl ether; hexane / 1.) room temperature, 4 h, 2.) -5 deg C, 1 h 3: NaBH4, 0.6 N NaOH / ethanol 4: HCl / dioxane / 4 h / 80 °C View Scheme

1: TMEDA, n-BuLi / diethyl ether; hexane / 1.) room temperature, 4 h, 2.) -5 deg C, 1 h 2: NaBH4, 0.6 N NaOH / ethanol 3: HCl / dioxane / 4 h / 80 °C View Scheme

1: 79.7 percent / 40percent peracetic acid / CH2Cl2 / 0.17 h / 0 °C 2: 86.1 percent / HCl gas / 1,2-dichloro-ethane / 10 h / 50 °C / Heating View Scheme