dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in 1,4-dioxane; water T=65°C; 20 h; Inert atmosphere;

1: dimethyl sulfoxide; toluene / 4 h / Reflux 2: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 20 h / 65 °C / Inert atmosphere View Scheme

1.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether; n-heptane; ethylbenzene / 1.67 h / -78 °C 1.2: 1 h / -78 °C 1.3: 0.25 h 2.1: dimethyl sulfoxide; toluene / 4 h / Reflux 3.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 20 h / 65 °C / Inert atmosphere View Scheme