1: With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-78 - 0°C; Inert atmosphere; 2: With triethylsilane in dichloromethane T=0 - 25°C; Inert atmosphere; 3: With sodium hydrogencarbonate in dichloromethane; water chemoselective reaction;

Schotten-Baumann acylation;

boric acid in toluene 48 h; Molecular sieveReflux;

potassium chloride in water T=25°C; Kinetics;

1.1: [Ir(μ-Cl)(cyclooctene)2]2; diethylesilane / 5 h / 23 °C / Inert atmosphere 2.1: hydrogenchloride / diethyl ether / 1 h / 23 °C / Inert atmosphere 2.2: 2 h / 23 °C / Inert atmosphere View Scheme