trichlorophosphate in N,N-dimethyl-formamide 8 h; Ambient temperature;

<b>Multi-step reaction with 2 steps<br /> </b>1: 98 percent / NaHCO₃ / H₂O; ethyl acetate / Ambient temperature<br />2: 70 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) sodium carbonate / 1.) water, acetone, 5 deg C, 1 h; 2.) 20 deg C, 1 h<br />2: 93 percent / toluene; acetic anhydride / 2 h / 50 &deg;C<br />3: 3.) acetic acid / 1.) pyridine, r.t., 1 h; 2.) 50-60 deg C, 2 h; 3.) 55 deg C, 2 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 93 percent / toluene; acetic anhydride / 2 h / 50 &deg;C<br />2: 3.) acetic acid / 1.) pyridine, r.t., 1 h; 2.) 50-60 deg C, 2 h; 3.) 55 deg C, 2 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 1.) sodium carbonate / 1.) water, acetone, 5 deg C, 1 h; 2.) 20 deg C, 1 h<br />2: toluene; acetic anhydride / 2 h / 50 &deg;C<br />3: 67 percent / triethylamine / ethyl acetate / 1 h / 0 &deg;C<br />4: 1.) pyridine / 1.) 25 deg C, 30 min; 2.) 60-70 deg C, 2 h<br />5: acetic acid / 3 h / 80 - 90 &deg;C<br /> <br /> &nbsp;