乙基[2-(4-氯苯基)-5-(2-呋喃基)-1,3-恶唑-4-基]乙酸酯合成路线 （共 4 条）
反应条件
trichlorophosphate in N,N-dimethyl-formamide
8 h; Ambient temperature;
参考文献
Moriya; Seki; Takabe; Matsumoto; Takashima; Mori; Odawara; Takeyama
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1197 - 1204
反应条件
1: 98 percent / NaHCO3 / H2O; ethyl acetate / Ambient temperature
2: 70 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min
3: 86 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature
View Scheme
参考文献
Moriya; Seki; Takabe; Matsumoto; Takashima; Mori; Odawara; Takeyama
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1197 - 1204
反应条件
1: 98 percent / NaHCO3 / H2O; ethyl acetate / Ambient temperature
2: 70 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min
3: 86 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature
View Scheme
参考文献
Moriya; Seki; Takabe; Matsumoto; Takashima; Mori; Odawara; Takeyama
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1197 - 1204
反应条件
1: 70 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min
2: 86 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature
View Scheme
参考文献
Moriya; Seki; Takabe; Matsumoto; Takashima; Mori; Odawara; Takeyama
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1197 - 1204
