反应条件
1: sodium ethanolate / ethanol / 15 h / 150 °C
2: trichlorophosphate / 0.5 h / 80 °C
3: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C
4: triethylamine / ethanol / 25 h / 80 - 100 °C
5: caesium carbonate / dimethyl sulfoxide / 5 h / 100 °C
6: sodium hydroxide; water / ethanol / 1 h / 60 °C
7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 10 - 35 °C / Cooling
View Scheme
参考文献
Ohashi, Tomohiro; Oguro, Yuya; Tanaka, Toshio; Shiokawa, Zenyu; Tanaka, Yuta; Shibata, Sachio; Sato, Yoshihiko; Yamakawa, Hiroko; Hattori, Harumi; Yamamoto, Yukiko; Kondo, Shigeru; Miyamoto, Maki; Nishihara, Mitsuhiro; Ishimura, Yoshimasa; Tojo, Hideaki; Baba, Atsuo; Sasaki, Satoshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 18 p. 5507 - 5517
