1: With trifluoroacetic acid in dichloromethane T=20°C; 1 h; 2: With sodium hydroxide in dichloromethane; water

1: 3,3-diphenyl-1-propanoic acid With oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide T=0°C; 0.5 h; 2: piperazine-1-carboxylic acid tert-butyl ester With pyridine in dichloromethane; N,N-dimethyl-formamide T=20°C; 18 h;

hydrogenchloride in methanol; water T=100°C; Yield given;

hydrogenchloride; palladium on activated charcoal Hydrogenation;

1: HOBT, DCC / dimethylformamide / Ambient temperature 2: HCl / methanol; H2O / 100 °C View Scheme

1: diethyl ether 2: palladium/charcoal; aq.-ethanolic HCl / Hydrogenation View Scheme