9,10-二氢-5-甲氧基-9-氧代-4-吖啶甲酸合成路线 (共 7 条)
反应条件
sulfuric acid T=90°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 3 p. 363 - 367
参考文献
Rewcastle, Gordon W.; Denny, William A.
Synthesis, 1985 , # 2 p. 217 - 220
反应条件
1: 97 percent / H2, aq. NaHCO3 / Pd/C 2: K2CO3, Cu, CuBr, N-methylpyrrolidinone / 2-ethoxy-ethanol / 2 h / 150 °C 3: H2SO4 / 4 h / 90 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 3 p. 363 - 367
反应条件
1: cuprous chloride, N-ethylmorpholine / benzene; various solvent(s) / 1 h / 120 °C 2: polyphosphoric acid / 1 h / 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 4 p. 472 - 477
反应条件
2: 78 percent / N-ethylmorpholine / CuCl / benzene; various solvent(s) / 1 h / Heating 3: 80 percent / polyphosphoric acid / 2 h / 120 °C View Scheme
参考文献
Synthesis, , # 2 p. 217 - 220
反应条件
1: K2CO3, Cu, CuBr, N-methylpyrrolidinone / 2-ethoxy-ethanol / 2 h / 150 °C 2: H2SO4 / 4 h / 90 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 3 p. 363 - 367
反应条件
1: cuprous chloride, N-ethylmorpholine / benzene; various solvent(s) / 1 h / 120 °C 2: polyphosphoric acid / 1 h / 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 4 p. 472 - 477