2-[(2-羧基苯基)氨基]-3-甲氧基苯甲酸合成路线 （共 4 条）
反应条件
sulfuric acid T=90°C; 4 h;
参考文献
Stankiewicz-Drogon, Anna; Doerner, Bernd; Erker, Thomas; Boguszewska-Chachulska, Anna M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3117 - 3126
反应条件
1: 97 percent / H2, aq. NaHCO3 / Pd/C
2: K2CO3, Cu, CuBr, N-methylpyrrolidinone / 2-ethoxy-ethanol / 2 h / 150 °C
View Scheme
参考文献
Denny; Atwell; Baguley
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 363 - 367
反应条件
1-methyl-pyrrolidin-2-one; copper; potassium carbonate; copper(I) bromide in 2-ethoxy-ethanol
T=150°C; 2 h;
参考文献
Denny; Atwell; Baguley
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 363 - 367
反应条件
copper; potassium carbonate in ethanol
1.5 h; Reflux;
参考文献
Doerner, Bernd; Kuntner, Claudia; Bankstahl, Jens P.; Bankstahl, Marion; Stanek, Johann; Wanek, Thomas; Stundner, Gloria; Mairinger, Severin; Loescher, Wolfgang; Mueller, Markus; Langer, Oliver; Erker, Thomas
Journal of Medicinal Chemistry, 2009 , vol. 52, # 19 p. 6073 - 6082
