4-[(苯基硫代)甲基]苯甲酸甲酯合成路线 （共 10 条）
反应条件
1: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 30 min 2: m-chloroperbenzoic acid / CH2Cl2 / 0.25 h / -78 °C 3: 100 percent / dimethylformamide / 1 h / 110 °C View Scheme
参考文献
DeGraw; Christie; Brown; Kelly; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 376 - 380
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=0°C; 2 h;
参考文献
NOVO NORDISK A/S
Patent: WO2005/58845 A2, 2005 ;
Location in patent: Page/Page column 38 ;
WO 2005/058845 A2
反应条件
in acetonitrile
T=80°C; 3 h; Sealed tube;
参考文献
Pan, Xiangcheng; Curran, Dennis P.
Organic Letters, 2014 , vol. 16, # 10 p. 2728 - 2731
反应条件
sulfuric acid in methanol
24 h; Heating;
参考文献
DeGraw; Christie; Brown; Kelly; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 376 - 380
反应条件
sodium in methanol
2 h; Heating;
参考文献
El-Zahraa Fatma; El-Hegazy, M.; El-Bardan, Ali A.; Hamed, Ezzat A.
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 88, # 1-4 p. 113 - 122
反应条件
1: 95 percent / 10percent Na2CO3 / 3 h
2: 80 percent / concd H2SO4 / methanol / 24 h / Heating
View Scheme
参考文献
DeGraw; Christie; Brown; Kelly; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 376 - 380
反应条件
1: 95 percent / 10percent Na2CO3 / 3 h
2: 80 percent / concd H2SO4 / methanol / 24 h / Heating
View Scheme
参考文献
DeGraw; Christie; Brown; Kelly; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 376 - 380
反应条件
1: 85 percent / conc. H2SO4 / 10 h / Heating
2: 90 percent / Na / methanol / 2 h / Heating
View Scheme
参考文献
El-Zahraa Fatma; El-Hegazy, M.; El-Bardan, Ali A.; Hamed, Ezzat A.
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 88, # 1-4 p. 113 - 122
反应条件
sodium hydride
1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 30 min; Multistep reaction;
参考文献
DeGraw; Christie; Brown; Kelly; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 376 - 380
反应条件
Oxone in methanol; water
T=0 - 20°C;
参考文献
SK CHEMICALS, CO., LTD.; IN2GEN CO., LTD.
Patent: WO2003/87066 A1, 2003 ;
Location in patent: Page/Page column 21-22 ;
WO 03/087066 A1
