3-氟-5-硝基苯甲酸甲酯合成路线 （共 4 条）
反应条件
ammonium chloride in ethanol
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
Location in patent: Page/Page column 68 ;
反应条件
thionyl chloride in methanol
参考文献
AGIOS PHARMACEUTICALS, INC; Lemieux, Rene M.; Popovici-Muller, Janeta; Travins, Jeremy; Cai, Zhenwei; Cui, Dawei; Zhou, Ding
Patent: US2013/190249 A1, 2013 ;
Location in patent: Page/Page column ;
反应条件
thionyl chloride
T=0 - 20°C; 6 h; Inert atmosphere;
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
Location in patent: Page/Page column 68 ;
反应条件
1: With lithium borohydride in tetrahydrofuran; diethyl ether
T=17 - 25°C; 2 h;
2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether
T=17 - 25°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/40526 A1, 2006 ;
Location in patent: Page/Page column 126-127 ;
WO 2006/040526 A1
