1-(3,4-二甲氧基苯基)-2-丁酮合成路线 （共 5 条）
反应条件
1: hydrolysis
2: 6 percent / R4 medium; thiostrepton; Streptomyces coelicolor CH999/pIJ5660 recombinant strain / methanol; dimethylformamide; glycerol / 96 h / 30 °C
View Scheme
参考文献
Booker-Milburn, Kevin I.; Gillan, Rebecca; Kimberley, Meriel; Taguchi, Takaaki; Ichinose, Koji; Richard Stephenson; Ebizuka, Yutaka; Hopwood, David A.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 7 p. 1121 - 1125
反应条件
in tetrahydrofuran
T=0°C;
参考文献
Gerritz; Smith; Nanthakumar; Uehling; Cobb
Organic letters, 2000 , vol. 2, # 25 p. 4099 - 4102
反应条件
toluene-4-sulfonic acid in xylene
5.5 h; Heating; Yield given;
参考文献
Hill, Kenneth A.; Peterson, Dorothy M.; Damodaran, Kalyani M.; Rao, P. Narasimha
Steroids, 1981 , vol. 37, # 3 p. 327 - 344
反应条件
1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
2: p-TosOH / xylene / 5.5 h / Heating
View Scheme
参考文献
Hill, Kenneth A.; Peterson, Dorothy M.; Damodaran, Kalyani M.; Rao, P. Narasimha
Steroids, 1981 , vol. 37, # 3 p. 327 - 344
反应条件
1: tetra-n-butyl ammonium hydrogen sulfate, NaOH / CH2Cl2; H2O / 16 h / Ambient temperature
2: LiBu / tetrahydrofuran; hexane / 0.33 h / -78 °C
3: p-TosOH / 1 h / 190 °C
4: 480 mg / BBr3 / CH2Cl2 / 1) -78 deg C, 2) -78 deg C to r.t. overnight
View Scheme
参考文献
Hill, Kenneth A.; Peterson, Dorothy M.; Damodaran, Kalyani M.; Rao, P. Narasimha
Steroids, 1981 , vol. 37, # 3 p. 327 - 344
