2,6-双(三氟甲基)嘧啶-4-醇合成路线 （共 4 条）
反应条件
1: With sodium methylate in methanol
20 h; Reflux;
2: With hydrogenchloride in methanol; water
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; MIZUNO, Hajime
Patent: WO2010/134478 A1, 2010 ;
Location in patent: Page/Page column 167 ;
反应条件
acetic acid; zinc in diethyl ether
2 h;
参考文献
Banks, Ronald E.; Pritchard, Robin G.; Thomson, Julie
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1769 - 1776
反应条件
hydrogenchloride; sodium hydroxide; potassium tert-butylate
1) THF, <60 deg C; 2) THF; 3) H2O, reflux, 2 h; 4) 80 deg C; Yield given. Multistep reaction;
参考文献
Sing; Lee
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 1 p. 7 - 9
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene
T=80°C; 3 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; MIZUNO, Hajime
Patent: WO2010/134478 A1, 2010 ;
Location in patent: Page/Page column 168 ;
