3-(4-氰基四氢-2H-吡喃-4-基)苯甲酸合成路线 （共 4 条）
反应条件
hydrogenchloride in tetrahydrofuran; methanol; water
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/137595 A1, 2009 ;
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol
T=20°C;
2: With hydrogenchloride in water
pH=1;
参考文献
N.V. ORGANON; FOLMER, Brigitte, Johanna, Bernita; MAN, de, Adrianus, Petrus, Antonius; GERNETTE, Elisabeth, Sophia; CORTE REAL GONCALVES AZEVEDO, Rita; IBRAHIM, Hemen
Patent: WO2011/147764 A1, 2011 ;
Location in patent: Page/Page column 55 ;
反应条件
1.1: N,N-dimethyl-formamide / 20 °C
2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 50 h / 20 °C
2.2: 18 h / 20 °C
3.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 20 °C
3.2: pH 1
View Scheme
参考文献
N.V. ORGANON; FOLMER, Brigitte, Johanna, Bernita; MAN, de, Adrianus, Petrus, Antonius; GERNETTE, Elisabeth, Sophia; CORTE REAL GONCALVES AZEVEDO, Rita; IBRAHIM, Hemen
Patent: WO2011/147764 A1, 2011 ;
反应条件
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 50 h / 20 °C
1.2: 18 h / 20 °C
2.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 20 °C
2.2: pH 1
View Scheme
参考文献
N.V. ORGANON; FOLMER, Brigitte, Johanna, Bernita; MAN, de, Adrianus, Petrus, Antonius; GERNETTE, Elisabeth, Sophia; CORTE REAL GONCALVES AZEVEDO, Rita; IBRAHIM, Hemen
Patent: WO2011/147764 A1, 2011 ;
