1: With sodium periodate in ethanol; water 2: With ammonia in ethanol; water 3: With hydrogen; palladium dihydroxide in ethanol; water P=2585.81 Torr; 48 h;

hydrogenchloride in water; ethyl acetate T=20°C; 3 h;

1.1: dihydrogen peroxide; acetic acid / toluene / Reflux 1.2: Reflux 2.1: sulfuryl dichloride / methanol / 0 - 20 °C 3.1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran / 0 - 20 °C 4.1: sulfuryl dichloride / dichloromethane / 0 - 20 °C 5.1: ethanol / 20 °C 6.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 6.2: 5.16 h / 0 - 20 °C 7.1: dihydrogen peroxide; sodium hydroxide / ethanol / 50 °C 8.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 16 h / 110 °C 9.1: hydrogenchloride / water; ethyl acetate / 3 h / 20 °C View Scheme

1.1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran / 0 - 20 °C 2.1: sulfuryl dichloride / dichloromethane / 0 - 20 °C 3.1: ethanol / 20 °C 4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 4.2: 5.16 h / 0 - 20 °C 5.1: dihydrogen peroxide; sodium hydroxide / ethanol / 50 °C 6.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 16 h / 110 °C 7.1: hydrogenchloride / water; ethyl acetate / 3 h / 20 °C View Scheme

1.1: sulfuryl dichloride / methanol / 0 - 20 °C 2.1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran / 0 - 20 °C 3.1: sulfuryl dichloride / dichloromethane / 0 - 20 °C 4.1: ethanol / 20 °C 5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 5.2: 5.16 h / 0 - 20 °C 6.1: dihydrogen peroxide; sodium hydroxide / ethanol / 50 °C 7.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 16 h / 110 °C 8.1: hydrogenchloride / water; ethyl acetate / 3 h / 20 °C View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 1.2: 5.16 h / 0 - 20 °C 2.1: dihydrogen peroxide; sodium hydroxide / ethanol / 50 °C 3.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 16 h / 110 °C 4.1: hydrogenchloride / water; ethyl acetate / 3 h / 20 °C View Scheme

1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 16 h / 110 °C 2: hydrogenchloride / water; ethyl acetate / 3 h / 20 °C View Scheme

1: dihydrogen peroxide; sodium hydroxide / ethanol / 50 °C 2: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 16 h / 110 °C 3: hydrogenchloride / water; ethyl acetate / 3 h / 20 °C View Scheme

1.1: ethanol / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 2.2: 5.16 h / 0 - 20 °C 3.1: dihydrogen peroxide; sodium hydroxide / ethanol / 50 °C 4.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 16 h / 110 °C 5.1: hydrogenchloride / water; ethyl acetate / 3 h / 20 °C View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide / 0.58 h / 0 °C / |Inert atmosphere 1.2: 16 h / 23 °C / |Inert atmosphere 2.1: pyridinium tribromide / 1,4-dioxane / 1.17 h / 23 °C / |Inert atmosphere 3.1: zinc; ammonium chloride / tetrahydrofuran / 16 h / 23 °C / |Inert atmosphere 4.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C / |Inert atmosphere 5.1: hydrogenchloride / 1,4-dioxane / 1 h / 23 °C / |Inert atmosphere 5.2: 15 h / 70 °C / |Inert atmosphere View Scheme