N-[4-(9-吖啶基氨基)-3-(二甲基氨基)苯基]甲烷磺酰胺合成路线 （共 3 条）
反应条件
1: 82 percent / pyridine / 1,2-dimethoxy-ethane / 1.) 20 deg C, 1 h, 2.) 100 deg C, 30 min
2: H2O / 12 h / 100 °C
3: H2 / Pd/C / methanol
4: acid
View Scheme
参考文献
Atwell, Graham J.; Rewcastle, Gordon W.; Denny, William A.; Cain, Bruce F.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 367 - 372
反应条件
1: H2O / 12 h / 100 °C
2: H2 / Pd/C / methanol
3: acid
View Scheme
参考文献
Atwell, Graham J.; Rewcastle, Gordon W.; Denny, William A.; Cain, Bruce F.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 367 - 372
反应条件
hydrogenchloride in methanol
Heating;
参考文献
Rewcastle, Gordon W.; Baguley, Bruce C.; Atwell, Graham J.; Denny, William A.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1576 - 1581
