2,4,5-三氟苯甲酰氯合成路线 （共 26 条）
反应条件
oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide T=20°C; 24 h; Inert atmosphere;
参考文献
Dubar, Faustine; Anquetin, Guillaume; Pradines, Bruno; Dive, Daniel; Khalife, Jamal; Biot, Christophe
Journal of Medicinal Chemistry, 2009 , vol. 52, # 24 p. 7954 - 7957
反应条件
in N-methyl-acetamide
反应条件
1: dimethylformamide / 17 h / Heating 2: aq. H2SO4 / 2 h / Heating 3: (COCl)2, DMF / CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991
反应条件
1: aq. H2SO4 / 2 h / Heating 2: (COCl)2, DMF / CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991
反应条件
1: 1.) aluminum chloride / 1.) 50 deg C, 1 h, 2.) 80 deg C, 22 h 2: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C 3: thionyl chloride / 4 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 168 - 174
反应条件
1: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C 2: thionyl chloride / 4 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 168 - 174
反应条件
in tetrahydrofuran 0.5 h; Ambient temperature; Yield given;
参考文献
Terauchi, Hideo; Tanitame, Akihiko; Tada, Keiko; Nishikawa, Yoshinori
Heterocycles, 1996 , vol. 43, # 8 p. 1719 - 1734
反应条件
1: propanedioic acid monoethyl ester With n-butyllithium; triphenylemethane in tetrahydrofuran Metallation; 2: 2,4,5-Trifluorobenzoyl chloride in tetrahydrofuran T=20°C; Acetylation; 1 h;
参考文献
Jung, Michael E.; Yang, Eric C.; Vu, Binh T.; Kiankarimi, Mehrak; Spyrou, Emmanouil; Kaunitz, Jon
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3899 - 3909
反应条件
1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in acetonitrile T=20°C; Transmetallation; 2.5 h; 2: 2,4,5-Trifluorobenzoyl chloride With triethylamine in acetonitrile T=20°C; Acylation; Decarboxylation; 16 h;
参考文献
Hay, Alastair M.; Hobbs-Dewitt, Sheila; MacDonald, Alasdair A.; Ramage, Robert
Synthesis, 1999 , # 11 p. 1979 - 1985
反应条件
1: diethylmalonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=20 - 25°C; 2.5 h; 2: 2,4,5-Trifluorobenzoyl chloride With triethylamine in acetonitrile T=20°C; 18 h;
参考文献
Baker, William R.; Cai, Shaopei; Dimitroff, Martin; Fang, Liming; Huh, Kay K.; Ryckman, David R.; Shang, Xiao; Shawar, Ribhi M.; Therrien, Joseph H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4693 - 4709
