7-甲基-N-(2-(甲基氨基)苯基)-2-丙基-3H-苯并咪唑-5-羧酰胺合成路线 (共 3 条)
反应条件
1: With PPA T=150 - 155°C; 2: With sodium hydroxide in water T=70 - 80°C; pH=5 - 6; 0.5 - 0.75 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/44754 A2, 2006 ;
Location in patent: Page/Page column 31 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane
Heating / reflux;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/44754 A2, 2006 ;
Location in patent: Page/Page column 31 ;
反应条件
polyphosphoric acid
T=150 - 155°C;
参考文献
Reddy, Kikkuru Srirami; Srinivasan, Neti; Reddy, Chinta Raveendra; Kolla, Naveenkumar; Anjaneyulu, Yerremilli; Venkatraman, Sundaram; Bhattacharya, Apurba; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 81 - 85