反应条件
1: 2-fluoro-5-chloropyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; n-heptane
T=-78°C; 1 h;
2: carbon dioxide in tetrahydrofuran; n-heptane
T=-78 - 20°C; 0.666667 h;
参考文献
AMGEN INC.; WHITE, Ryan; CHENG, Yuan; MINATTI, Ana Elena; YANG, Bryant; ZHENG, Xiao Mei; LOPEZ, Patricia; HUMAN, Jason B.; EPSTEIN, Oleg; JUDD, Ted; SHAM, Kelvin; XUE, Qiufen
Patent: WO2013/44092 A1, 2013 ;
Location in patent: Page/Page column 85 ;
