2-甲氧基-3-溴-5-氟吡啶合成路线 （共 3 条）
反应条件
silver carbonate in toluene T=20°C;
参考文献
ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob
Patent: WO2011/6074 A1, 2011 ;
Location in patent: Page/Page column 74-75 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes T=-100°C; 2 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; hexanes; water T=0°C; 1 h;
参考文献
Almirall, S.A.
Patent: EP2463289 A1, 2012 ;
Location in patent: Page/Page column 21 ;
EP 2463289 A1
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=80°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/141119 A2, 2008 ;
Location in patent: Page/Page column 105 ;
WO 2008/141119 A2
