2-甲基-6-氯吡啶-3-甲醛合成路线 (共 2 条)
反应条件
1: 5-bromo-2-chloro-6-methylpyridine With n-butyllithium in diethyl ether T=-78 - -70°C; 0.5 h; 2: N,N-dimethyl-formamide in diethyl ether T=-78 - 20°C; 1.5 h;
参考文献
ANORMED INC.
Patent: WO2007/22371 A2, 2007 ;
Location in patent: Page/Page column 50 ;
WO 2007/022371 A2
反应条件
1: With diisobutylaluminium hydride in dichloromethane T=0°C; 1 h; 2: With water; citric acid in dichloromethane 1 h; 3: With sodium hydrogencarbonate in dichloromethane; water
参考文献
WO2009/58923 A1, ;
Page/Page column 16 ;
WO 2009/058923 A1