1: methyllithium With copper (I) cyanide in tetrahydrofuran; diethyl ether T=-78 - 20°C; 2: (2S,3S)-N-para-toluenesulfonyl-3-methylaziridine-2-carboxylic acid in tetrahydrofuran; diethyl ether T=20°C; 18 h; Further stages. Title compound not separated from byproducts.;

Yield given. Yields of byproduct given. Title compound not separated from byproducts;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=20&deg;C;&nbsp;3&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 600 mg / H₂O; ethyl acetate / 20 h / 20 &deg;C<br />2: 100 percent / aq. NaOH / tetrahydrofuran / 3 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: i-Pr₂EtN<br />2: H⁺ <br />3: PPh₃; diethyl azodicarboxylate<br />4: 100 percent / lithium hydroxide monohydrate / tetrahydrofuran; H₂O / 24 h / 50 &deg;C<br /> <br /> &nbsp;