1: phenyllithium With copper (I) cyanide in tetrahydrofuran; anhydrous butyl ether T=-78 - 20°C; 0.5 h; 2: (2S)-N-para-toluenesulfonylaziridine-2-carboxylic acid in tetrahydrofuran; anhydrous butyl ether T=-78 - 20°C; 21 h; Further stages.;

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1.1: copper(I) cyanide / dibutyl ether; tetrahydrofuran / 0.5 h / -78 - 20 °C 1.2: 57 percent / dibutyl ether; tetrahydrofuran / 21 h / -78 - 20 °C 2.1: 42 percent / HBr; phenol / acetic acid / 4.5 h / 20 °C View Scheme

1: isopropyllithium With copper (I) cyanide in tetrahydrofuran; pentane T=-78 - 0°C; 2: (2S)-N-para-toluenesulfonylaziridine-2-carboxylic acid in tetrahydrofuran; pentane T=-78 - 20°C; Further stages.;