1-(3-三氟甲基苯氧基)-3-炔-2-丁醇合成路线 （共 7 条）
参考文献
Danilova, N. A.; Miftakhov, M. S.; Lopp, M. I.; Lille, Yu. E.; Tolstikov, G. A.
Doklady Chemistry, 1983 , vol. 273, p. 375 - 377
Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 273, # 3 p. 620 - 622
反应条件
1: 84.3 percent / K2CO3 / 1-methyl-pyrrolidin-2-one / 8 h / 140 - 150 °C
2: aq. H2SO4 / tetrahydrofuran / Heating
3: 778 g / tetrahydrofuran / 2.5 h / 20 °C
View Scheme
参考文献
Fox, Martin E.; Jackson, Mark; Lennon, Ian C.; McCague, Raymond; Parratt, Julian S.
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 1 p. 50 - 56
反应条件
1: aq. H2SO4 / tetrahydrofuran / Heating
2: 778 g / tetrahydrofuran / 2.5 h / 20 °C
View Scheme
参考文献
Fox, Martin E.; Jackson, Mark; Lennon, Ian C.; McCague, Raymond; Parratt, Julian S.
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 1 p. 50 - 56
反应条件
1: 90 percent / diisobutylaluminium hydride / diethyl ether / -70 °C
2: 1) ethylbromide, Mg / 1) THF, colling with ice; 2) THF, 18 h, room temp.
View Scheme
参考文献
Tolstikov, G. A.; Miftakhov, M. S.; Danilova, N. A.; Galin, F. Z.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1624 - 1631
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1857 - 1866
反应条件
1: 90 percent / i-Bu2AlH / -70 °C
2: 85 percent
View Scheme
参考文献
Danilova, N. A.; Miftakhov, M. S.; Lopp, M. I.; Lille, Yu. E.; Tolstikov, G. A.
Doklady Chemistry, 1983 , vol. 273, p. 375 - 377
Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 273, # 3 p. 620 - 622
反应条件
ethyl bromide; magnesium
1) THF, colling with ice; 2) THF, 18 h, room temp.; Yield given. Multistep reaction;
参考文献
Tolstikov, G. A.; Miftakhov, M. S.; Danilova, N. A.; Galin, F. Z.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1624 - 1631
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1857 - 1866
反应条件
1H-imidazole in N,N-dimethyl-formamide
1) 5 gradC, 1.5 h; 2) room temp., 18 h;
参考文献
Tolstikov, G. A.; Miftakhov, M. S.; Danilova, N. A.; Galin, F. Z.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1624 - 1631
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1857 - 1866
