sodium; ammonium chloride in ammonia

triethylamine; trifluoroacetic anhydride in tetrahydrofuran 0.5 h; Ambient temperature;

1: 5 Angstroem molecular sieves / CH2Cl2 / 4 h / Heating 2: 55.6 mg / ZrCl4 / acetonitrile; CH2Cl2 / 1 h / 23 °C View Scheme

hydrogenchloride in 1,4-dioxane 0.5 h; Ambient temperature;

hydrogenchloride in 1,4-dioxane; water

sodium; ammonium chloride in ammonia

1: hydrogenchloride / water / 0.25 h / 25 °C 2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / water / 60 °C / |Microwave irradiation 3: hydrogenchloride / water / 0.25 h / 25 °C 4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / water / 60 °C / |Microwave irradiation 5: hydrogenchloride / water / 0.25 h / 25 °C 6: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / water / 60 °C / |Microwave irradiation 7: hydrogenchloride / water / 0.25 h / 25 °C 8: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / water / 60 °C / |Microwave irradiation 9: palladium 10 on activated carbon; ammonium formate / methanol / |Reflux View Scheme

sodium; ammonium chloride in ammonia

1: 93 percent / TFAA / pyridine / 2.5 h / 0 °C 2: H2; NH3 / Raney Ni / H2O; ethanol / 4 h / 2250.18 Torr View Scheme

1: trifluoroacetic anhydride; pyridine / 0.5 h / 20 °C 2: methane sulfonic acid / tetrahydrofuran / 18 h / 20 °C View Scheme