3-(1-甲基环丙基)-3-氧丙腈合成路线 (共 3 条)
反应条件
1: 2-oxopropionitrile With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78°C;
2: 1-(methoxycarbonyl)-1-methylcyclopropane in tetrahydrofuran
T=-78 - 20°C;
参考文献
ABBOTT LABORATORIES
Patent: US2010/249129 A1, 2010 ;
Location in patent: Page/Page column 38 ;
US 20100249129 A1
反应条件
1: acetonitrile With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78°C; 1 h;
2: 1-(methoxycarbonyl)-1-methylcyclopropane in tetrahydrofuran
T=-78 - 20°C; 1 h;
参考文献
ABBOTT LABORATORIES
Patent: US2010/69348 A1, 2010 ;
Location in patent: Page/Page column 46; 47 ;
反应条件
1: acetonitrile With sodium hydride in tetrahydrofuran
T=20°C; 0.166667 h;
2: 1-(methoxycarbonyl)-1-methylcyclopropane in tetrahydrofuran
3 h; Heating / reflux; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/53346 A1, 2007 ;
Location in patent: Page/Page column 16 ;
WO 2007/053346 A1