反应条件
1.1: 70 percent / dibromodimethylhydantoin; sulfuric acid / acetonitrile / 2 h / 55 °C
2.1: bis(neopentylglycolato)diboron; potassium acetate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane; CH2Cl2 / 24 h / 80 °C
2.2: 97 percent / aq. HCl / 0.5 h / 40 °C
View Scheme
参考文献
Lewis, Richard T.; Blackaby, Wesley P.; Blackburn, Timothy; Jennings, Andrew S. R.; Pike, Andrew; Wilson, Rowan A.; Hallett, David J.; Cook, Susan M.; Ferris, Pushpinder; Marshall, George R.; Reynolds, David S.; Sheppard, Wayne F. A.; Smith, Alison J.; Sohal, Bindi; Stanley, Joanna; Tye, Spencer J.; Wafford, Keith A.; Atack, John R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2600 - 2610